Cleaved-CASP3 p12 (D175) Polyclonal Antibody.
Clonality: Polyclonal Antibody.
Antibody Isotype: IgG.
Conjugation: Unconjugated.
Concentration: 1mg/mL.
Immunogen: Synthesized peptide derived from the Internal region of human Caspase-3 p12.
Dilution: WB 1:500-2000, IHC 1:50-300, IF 1:50-300
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4.
Gene ID: 836.
Gene Accession no.
Swissprot No.P42574.
Research Areas:Cancer, Cell Biology, Metabolism, Neuroscience
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Please contact our support expert at support@clementiabiotech.com for data sheet, manuals & quote.
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