The members of the G protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors.The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. Members of thebeta-Arrestin family regulate receptor binding to G proteins.beta-Arrestins have been found to be located at postsynaptic sites, where they are thought to act in concert withbetaARK (βARK1, also designated GRK 2, orbetaARK2, also designated GRK 3) to regulate G protein-coupled neurotransmitter receptors. Expression ofbeta-Arrestin-1 andbeta-Arrestin-2 is seen predominantly in spleen and neuronal tissues. It has been shown thatbeta-Arrestin-1 expression is modulated by intracellular cAMP, which may be a novel mechanism for the regulation of receptor-mediated responses. Please contact our support expert at support@clementiabiotech.com for data sheet, manuals & quote.

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