ATXN1 Polyclonal Antibody.
Clonality: Polyclonal Antibody.
Antibody Isotype: IgG.
Conjugation: Unconjugated.
Concentration: 1mg/mL.
Immunogen: Synthesized peptide derived from human Ataxin-1 around the non-phosphorylation site of Ser776..
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4.
Gene ID: 6310.
Gene Accession no.
Swissprot No.P54253.
Research Areas:Epigenetics and Nuclear Signaling, Neuroscience
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. Please contact our support expert at support@clementiabiotech.com for data sheet, manuals & quote.
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