This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants.CYSLTR1 (Cysteinyl Leukotriene Receptor 1) is a Protein Coding gene. Diseases associated with CYSLTR1 include Asthma and Adenoid Hypertrophy. Among its related pathways are RET signaling and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is CYSLTR2. Please contact our support expert at support@clementiabiotech.com for data sheet, manuals & quote.

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