Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acidbeta-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-kB, causing inhibition of its signaling pathway or reducing the activated levels of NF-kB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase. Please contact our support expert at support@clementiabiotech.com for data sheet, manuals & quote.

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