Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.Isoform 2 may act as an antagonist of EGF action. Please contact our support expert at support@clementiabiotech.com for data sheet, manuals & quote.

https://www.clementiabiotech.com/products/affinity-biosciences-14-3-3-eta-antibody-affinity-biosciences-df3492-100ul-200ul https://www.clementiabiotech.com/products/affinity-biosciences-14-3-3-eta-antibody-affinity-biosciences-df3492-100ul-200ul https://www.clementiabiotech.com/products/affinity-biosciences-14-3-3-eta-antibody-affinity-biosciences-df3492-100ul-200ul https://www.clementiabiotech.com/products/affinity-biosciences-14-3-3-eta-antibody-affinity-biosciences-df3492-100ul-200ul